A PROMISING TECHNIQUE TO IMPROVE THE SOLUBILITY BY LIQUISOLID COMPACTION TECHNOLOGY
نویسندگان
چکیده
منابع مشابه
Solubility Enhancement of Carvedilol Using Liquisolid Compact Technique
A novel liquisolid compact technique was used for soulbility enahncement of poorly water soluble drug carvedilol (CAR). CAR was dissolved in water miscible non volatile solvent and then adsorbed on a solid carrier which was later compacted with other excipient into a tablet. The tablets were characterized with respect to hardness, friability, disintegration and in-vitro dissolution profile. Eff...
متن کاملAttempts and outcomes of liquisolid technology: An updated chronological compilation of innovative ideas and adjuvants in the field
It has been observed that most of the chemical entities have high lipophilicity and poor aqueous solubility, which result in poor bioavailability. In order to improve the bioavailability, the release behavior of such drugs should be improved. Although there are numerous techniques to handle solubility related issue, but they are expensive due to involvement of complicated equipments, advanced m...
متن کاملFormulation and Evaluation of Immediate Release Tablet of Carvedilol using Liquisolid Compacts Technique for Solubility Enhancement
Aim: The aim of this study was to formulate and evaluate liquisolid compact system of carvedilol to give increased dissolution rate of drug by utilizing PEG400 as the non-volatile liquid vehicle. Materials and Methods: The liquisolid tablets formulated with PEG400 at different concentrations. The suitable analytical method based on UV-visible spectrophotometer was developed for carvedilol. Resu...
متن کاملEmerging Liquisolid Compact Technology for Solubility Enhancement of BCS Class-II Drug
Diazepam possesses potent anti-epileptic, anti-anxiety activity and also indicated for the treatment of insomnia. It is very slightly soluble in water and shows poor dissolution. Presently, liquisolid compact technique is found to be used extensively as one of the successful tool to enhance the solubility and dissolution of various poorly soluble drugs. The principle focus of this study is to f...
متن کاملLiquisolid Systems to Improve the Dissolution of Furosemide
A liquisolid system has the ability to improve the dissolution properties of poorly water soluble drugs. Liquisolid compacts are flowing and compactable powdered forms of liquid medications. The aim of this study was to enhance the in vitro dissolution properties of the practically water insoluble loop diuretic furosemide, by utilising liquisolid technique. Several liquisolid tablets were prepa...
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ژورنال
عنوان ژورنال: Journal of Drug Delivery and Therapeutics
سال: 2018
ISSN: 2250-1177
DOI: 10.22270/jddt.v8i5.1919